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Transactions of the INDIAN CERAMIC SOCIETY   Vol. 76  2017
Preparation and Characterization of Sn-Containing Glasses for Brachytherapy Applications
Leila Bazli,* Bijan Eftekhari Yekta and Alirezakhavandi
Pages : 242-246
DOI : 10.1080/0371750X.2017.1374212
Abstract
Brachytherapy is one of the effective ways for cancer treatment. The -emitter 123Sn isotope has a half-life of 129.2 days and might be a good candidate for brachytherapy application. In this study, crystallization behaviour and chemical durability of glass particles based on SiO2-SnO system, which were prepared by melting in an inert atmosphere and quenching in water, were investigated. Crystallinity of the glasses was characterized by X-ray diffractometery and chemical durability of the samples was measured in the simulated body fluid at 37oC for over 14 days. A glass containing 55 mol% SiO2 and 45 mol% SnO showed the best chemical resistance. According to differential thermal analysis, X-ray diffraction patterns, scanning electron microscopy and energy-dispersive X-ray spectroscopy, SnSiO3 and SnO2 were crystallized in the glass during heat treatments at 720o, 800o and 900oC. Chemical resistance of the sample, which was assessed through Sn release from the specimens into SBF, was improved significantly after the mentioned heat-treatment procedure; moreover, the glass was not cytotoxic. Such specifications make such glass system suitable for brachytherapy application. [Keywords: Brachytherapy, Cancer, Glass, Chemical durability]
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