| Effect of Zinc Doping on Biological Properties of
Biphasic Calcium Phosphate Ceramics
in Orthopaedic Animal Model |
Howa Begam1, Somali Mandal1, Abhijit Chanda1, Jayanta Mukherjee2 and Samit Kumar Nandi*
Pages : 284-292
DOI : 10.1080/0371750X.2014.929509 |
| Abstract |
| Addition of dopants in biomaterial has emerged as a vital regulator of bone formation and bone regeneration due to
their significant role in the biological processes. We report the effect of zinc ion doping on various properties of
biphasic calcium phosphate (BCP) dense body in vitro and in vivo. Zinc (?3 wt%) was successfully incorporated into
both calcium hydroxyapatite (HAp) and ?-tricalcium phosphate (TCP) via simple wet chemical route. BCP pellets
were prepared by mixing HAp and TCP in a definite proportion, compacted and then sintered. The sintered pellets
were checked with XRD, FTIR in addition to hardness and fracture toughness. A systematic in vivo study was conducted
to evaluate healing of surgically created defects on the femur of rabbit after implantation of doped and undoped
dense BCP for 4 months. Characterization of these sintered dense bodies revealed that zinc dopant had marked
influence on the physical properties of the dense bodies as well as their mechanical properties. Fluorochrome labelling,
histological analysis and radiology were performed post operation after two and four months to study angiogenesis,
bone formation and osseous ingrowth. The findings suggested that addition of Zn dopants to the BCP ceramics
demonstrated excellent bone formation and that may pave the new insight in bone tissue engineering. |
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