| Synthesis and Physico-Chemical Characterization of
Different Mesoporous Bioactive Glass Nanopowders:
in-vitro SBF Activity and Cytotoxicity |
Akrity Anand,1 Biswanath Kundu,1,* Vamsi Krishna Balla1 and Samit Kumar Nandi2
Pages : 106-117
DOI : 10.1080/0371750X.2018.1465357 |
| Abstract |
| Mesoporous bioactive glass (MBG) nanopowders from SiO2-CaO-P2O5 system have
been prepared by three different variations using different structure directing
agents: (1) through wet chemical method (MBWC650) using non-ionic surfactant,
PEG; (2) using Pluronic P123, another non-ionic surfactant via hydrothermal
process (MBHM650); and (3) using ionic surfactant CTAB, via wet chemical process
(MBCTAB650). Comparative study of phase, morphology and textural properties
of all MBG nanopowders were accomplished by different characterization
techniques. Specific surface area of powders was found to be 52.2, 169.3 and
473.2 m2.g–1 for MBWC650, MBHM650 and MBCTAB650, respectively. Kinetic SBF
immersion study was carried out to examine hydroxyapatite forming ability of the
powders. Supernatant analyses showed high dissolution of Ca2+ and PO4
3- ions in
MBCTAB650 while MBHM650 showed initial level of HAp formation ability over its
surface in contrast with MBWC650. Other characterizations confirmed formation
of Ca-P over MBG nanopowders. Cell viability of 117% for MBWC650, 90% for
MBHM650 and 89% for MBCTAB650 after seven days were noted. MBHM650 and
MBWC650 could be suitable candidate as dental/orthopedic bone filler material
whereas high surface area of MBCTAB650 powder can be useful for delivering
pharmaceutical agents in-vitro / in-vivo.
[Keywords: Mesoporous bioactive glass, Specific surface area, Nanopore, SBF
bioactivity, Hydroxyapatite, MTT assay] |
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