| Surface Activation of Titanium Implant by Tricalcium
Phosphate Ceramic Based Composite Coating for Bone
Tissue Regeneration |
Selvakani Prabakaran,a,* Ravikumar Kavibharathi,a Kandasamy Vinothini,b Rajiv Periakaruppanc
and Nithya Chandrasekaranc
Pages : 252-264
DOI :10.1080/0371750X.2024.2431861 |
| Abstract |
| In order to replace and heal the injured bone tissue, implants made up of bioresorbable
materials in combination with osteoconductive calcium phosphate ceramics show
promising results. Moreover, for better osseointegration and accelerated bone fracture
repair of titanium (Ti) implant, its surface should be activated by nanocomposite
coatings.The objective of this research is to develop a multifunctional composite
coated Ti implant using zinc and potassium substituted -tricalcium phosphate
(MTCP), bovine serum albumin (BSA) and clove-cinnamon extract (CCE) (MTCP/BSA/
CCE) composite that would address the bone problems by fusing MTCP’s regenerative
qualities with antibacterial CCE. Morphology of the MTCP/BSA/CCE composite coated
Ti’s surface was accessed using scanning electron microscopic analysis. The
composites’ functionality and phase characteristics were accessed using Fourier
transform infrared spectroscopy and X-ray diffraction analysis, respectively. The antimicrobial
ability of the prepared composites was confirmed against Staphylococcus
aureus and Escherichia coli strains. Moreover, in-vitro findings suggest that, MTCP/
BSA/CCE composite significantly improves the growth of osteoblasts like MG-63 cells
(90%) at optimum concentration (20 g/mL), which is greater than the negative control
cisplatin (45%). Our research suggests that this technology could be used in
commercial medical devices to increase osseointegration and lower the risk of
bacterial infections, improving implantation success and patient satisfaction.
[Keywords: Antimicrobial activity, Bio-composite, Bone tissue regeneration, Natural
extract, Titanium implant, Tricalcium phosphate, Serum protein] |
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