| Effect of Process Variations on Anticancerous Drug
Intercalation in Ceramic Based Delivery System |
Manjusha Chakraborty*, Poulomi Bose, Tapan Mandal, Bakul Datta**, Tarak Das***,
Shilpa Pal****, Jui Chakraborty, Manoj Mitra***** and Debabrata Basu
Pages: 229-234
DOI : 10.1080/0371750X.2010.11090840 |
| Abstract |
| Two methods have been attempted to intercalate an anionic anticancerous drug methotrexate (MTX) into Mg-Al layered double hydroxide (LDH): a) anion exchange method (sample A) and b) in situ coprecipitation method followed by a soft hydrothermal treatment (sample A) to form a biohybrid material. Both the materials obtained were characterized by powdered sample X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), thermogravimetric-differential thermal analysis (TG-DTA), particle size distribution (PSD) analysis and field emission scanning electron microscopy (FE-SEM). High performance liquid chromatography (HPLC) was used to determine the integrity of the MTX and to quantify the drug loading in the materials. HPLC data of sample A confirms the integrity of the MTX moiety in the interlayer space of Mg-Al-LDH which has been further verified by XRD and FTIR spectroscopy and drug loading in the hybrid system was found to be 20.22 mg.g–1. However, the HPLC data of sample A supports that under soft hydrothermal condition decomposition of MTX is operating and the major decomposition product was identified as N10-methyl folic acid that remains adsorbed on Mg-Al-LDH surface, primarily, as indicated by the TG-DTA study. |
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